Sustained complete autonomic blockade

Heart-rate response to sustained hand grip: comparison of the effects of cardiac autonomic blockade and diabetic autonomic neuropathy.

1. The heart-rate response during sustained hand grip was studied in four normal subjects before and after intravenous atropine, propranolol and combined cardiac autonomic blockade with both drugs. The results suggest that the increase in heart rate during the first 30 s is due to parasympathetic withdrawal, whereas the further increase between 30 s and 180 s is probably mediated by a combinati...

Sustained complete response to CTLA-4 blockade in a patient with metastatic, castration-resistant prostate cancer.

We present the case of a man with metastatic, castration-resistant prostate cancer, who had a complete prostate-specific antigen (PSA) response after 2½ doses of ipilimumab. His treatment course was complicated by diarrhea and autoimmune hepatitis, both of which resolved within 4 months. Sera and biopsy specimens were accessed, and sera from pretreatment and day 113 were analyzed. Augmented ant...

Complete RAAS BloCkAde And itS CliniCAl SignifiCAnCe

Cancer Immunology Miniatures Sustained Complete Response to CTLA-4 Blockade in a Patient with Metastatic, Castration-Resistant Prostate Cancer

We present the case of a man with metastatic, castration-resistant prostate cancer, who had a complete prostate-specific antigen (PSA) response after 2/2 doses of ipilimumab. His treatment course was complicated by diarrhea and autoimmune hepatitis, both of which resolved within 4 months. Sera and biopsy specimens were accessed, and sera from pretreatment and day 113 were analyzed. Augmented an...

Autoimmune ganglionic blockade. A cause of autonomic failure. Focus on "Experimental Autoimmune Autonomic Neuropathy".

If we are seeking evidence about the importance of the autonomic nervous system in daily life, we need only witness the disabling nature of autonomic disorders. Patients with severe autonomic failure are unable to stand but for few seconds, before syncope ensue due to orthostatic hypotension. The autonomic nervous system modulates the function of virtually all organ systems; thus these patients...